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For class context, the geroscience literature evaluates compounds including rapamycin (FDA-approved mTOR inhibitor with NIH ITP-replicated mouse lifespan extension), metformin (FDA-approved Complex I / AMPK modulator with the ongoing TAME human trial), and dietary supplement-channel candidates such as NAD+ precursors and spermidine
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13 Burgeoning antibiotic-resistance rates are an argument against empiric therapy with clarithromycin-based regimens, as antibiotic resistance can lead to treatment failure and reinfection
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