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That said, when degradation becomes visible, these are the signs: Color change: Clear becoming yellow, amber, or brown (in non-B12 formulations) Cloudiness: Loss of transparency, haziness, or milky appearance Particles: Visible specks, fibers, crystals, or sediment Foaming: Excessive bubbles that do not resolve after gentle swirling Viscosity change: Solution becomes thicker or stickier than water-like consistency If your semaglutide shows none of these visual signs but you suspect it has been exposed to improper conditions, the safest approach is still to discard it and request a replacement