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Together these observations are consistent with an important concept: microglia are the earliest responders to a primary multifocal myelin injury in the MS white matter, and importantly, this injury/response seems to precede lymphocytic infiltration, arguing against adaptive immune cells being the primary drivers of white matter injury

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In a retrospective study, thirty-eight exposure-discordant monocygotic twins who sustained painful back injury in the past related to work, leisure or sport were interviewed