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Other studies indicate that ATP7B maintains cellular copper homeostasis by transporting copper to the Golgi apparatus for integration into copper-dependent enzymes, NFE2L2 (NRF2) activates various antioxidant enzymes to mitigate oxidative stress and inflammation caused by copper excess, and MTF1 detects abnormal metal concentrations and induces detoxification and stress-response gene expression (170)

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The study design was comparable to that used with AFFITOPE PD01A, with 36 patients randomized to a low dose, high dose, or placebo group