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Finally, relamorelin (also known as RM-131), a selective GHSR agonist [103], was shown to substantially improve symptoms of delayed gastric emptying in a randomized phase 1b trial of diabetic patients [104] and is currently in a clinical phase 2b trial for the treatment of diabetic gastroparesis [10,105]
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It is possible that the LKB1/AMPK/ACC pathway is activated by direct redox modulation of cellular proteins since activation of AMPK pathway has been directly linked to cellular redox status and hydrogen peroxide 49
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