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Physical exertion produces a hyperregulation of the nuclear factor kappa B and mitogen-activated protein kinase that activates gene expression of a number of enzymes and proteins with an important role in maintaining oxidative/antioxidant intracellular homeostasis ( Physical exercise is considered the main treatment of non-pharmacological therapies along with lifestyle changes for various chronic diseases, especially cardiovascular diseases (Ren and Taegtmeyer, 2015)
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