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There is evidence that NMDARs appear in neurons within the cortical plate soon after migrating from the VZ and that these are fully functional receptors (GluRs).[149] In mice, glutamate has been shown to be a powerful chemoattractant for neuronal migration from the VZ/SVZ.[17] Using ferrets, Herrmann demonstrated that glutamate was present in the VZ, intermediate zone, developing cortical plate, and marginal zone as early as embryonic day 34 (E34), seven day before birth.[106] GluR1 (GluA1- new nomenclature), a subunit of AMPARs, emerged more slowly, with only a few neurons having this subunit in the marginal zone and VZ, but became abundant in the marginal zone and subplate as synaptogenesis begins [Figure 1]
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Effects of chronic apical periodontitis on the inflammatory response of the aorta in hyperlipemic rats
