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Read the full Grape Skin Extract + Bosentan interaction Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate Interaction Summary Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant

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doi: 10.1002/phar.1890