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Several potential strategies are available to boost NAD + concentrations (in blood, myocardial cell, adipose tissue, liver, brain, or U2OS cells), including lifestyle changes (such as exercise [105,106], diet and caloric restriction [107,108], and enhancing circadian rhythm [109,110]), use of small-molecule inhibitors or activators to boost NAD + biosynthesis [72,[111], [112], [113], [114], [115], [116]],and supplementation with NAD + precursors (primarily NMN, NR, and NAM) (Figure 1) [22]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Dasgupta S, et al
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