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Following reduction, cysteines were alkylated by the addition of 20 mM chloroacetamide (400 mM) for 30 min at 37 °C

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Instead, several alternative explanations emerge, such as: Insufficient dosing relative to oxidative stress burden, short duration of administration prior to hypoxic exposure, failure to reach central nervous system target sites and hypoxia-induced alterations in absorption, distribution, metabolism, and elimination