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However, their impact on hydration status should not be underestimated, as adequate fluid intake becomes particularly important during this adjustment period
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The predominant mechanism involves blocking DNA binding, as employed by eleven characterized Acr proteins: six prevent target DNA hybridization with the crRNA guide (AcrIF1, AcrIF8, AcrIF9, AcrIF13, AcrIF14, AcrIF24), and five disrupt PAM recognition through direct or allosteric mechanisms (AcrIF2, AcrIF6, AcrIF7, AcrIF10, AcrIF11)
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