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A new PET tracer of mitochondrial complex I function, 18 F-labelled 2- tert -butyl-4-chloro-5–2 H -pyridazin-3-one 278 , has been proposed as a marker of mitochondrion-specific energy failure arising before the onset of impaired glycolysis in AD, and could be used to validate new therapeutics aiming to correct mitochondrial function
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PubMed Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B
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