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In 2020, a related study (28) demonstrated that overexpression of miR-140-3p inhibited the proliferation of human cervical cancer cells by targeting down-regulation of RRM2 inducing cell cycle arrest and early apoptosis, while decreasing BCL-2 protein levels and inducing a significant increase in BAX and caspase-3 protein levels

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BAX and BAK oligomerize at the OMM and for a transmembrane pore, resulting in mPTP opening, loss of MMP, and release of mitochondrial intermembrane space proteins, such as cytochrome c, apoptosis-inducing factor, and endonuclease G (Schellenberg et al., 2013)