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Its derivatives comprise artemether (ARM), arteether (ARTE), dihydroartemisinin (DHA), and artesunate (ATS), and various derivatives have been reported to induce ferroptosis in tumor cells ( Artemisinin can induce ferroptosis of tumor cells through multiple mechanisms, such as triggering intracellular ROS production, promoting lysosomal degradation of ferritin, and regulating the System Xc-/GPX4 axis to induce ferroptosis ( Alkaloids induce ferroptosis in tumor cells Solasonine, a steroidal alkaloid derived from the natural herb Solanum melongena, exhibits potent anticancer activity

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This novel RCD mechanism does not exhibit typical apoptotic characteristics, such as nuclear fragmentation and cysteine asparaginase activation [18]