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Notably, a study demonstrated that manganese SOD2 (MnSOD2), a key mitochondrial antioxidant enzyme, was directly activated by SIRT3 through deacetylation [107], enhancing its ability to neutralize superoxide radicals

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In one embodiment, when one or more buffers are utilized in the formulations of the present disclosure, they are combined, e.g., with a pharmaceutically acceptable vehicle and are present in the final formulation, e.g., in an amount ranging from about 0.1% to about 20%, from about 0.5% to about 10%

or prevent any disease.