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In the field of histone modification, panobinostat, an HDAC inhibitor that belongs to the cinnamic hydroxamic acid class of compounds that inhibits HDAC1, 3–6 at nanomolar concentrations [133, 134], has exhibited cytotoxic effects by inducing cell cycle arrest and apoptosis in ATC cell lines both in vitro and in vivo [51], but its clinical efficacy remains limited
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The remaining zinc is incorporated into complexes with numerous Zn 2+ -binding proteins and, depending on binding affinity, can play a structural and functional role or exhibit signaling activity by being redistributed among signal transduction proteins (so-called “mobile” or “loosely bound” zinc) 3,4,5
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