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NRF2 is transferred to the nucleus, recognizes and binds to antioxidant response elements (AREs), and regulates ferroptosis-related genes, thereby regulating ferroptosis (Rojo de la Vega et al., 2018)
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KHK-mediated fructolysis promotes the accumulation of dihydroxyacetone phosphate (DHAP), which serves as a precursor for methylglyoxal (MGO) production (Fig
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